Endocrine Abstracts

Introduction: Secondary hormonal deficiencies (SHD) are frequently observed in patients with pituitary adenomas. We previously reported that pituitary tumour clinical subtypes were associated with specific patterns of SHD, and nonfunctioning adenomas (NFAs) were more likely to present with multiple SHD. We extended our work to examine if the immunohistochemical staining patterns of NFAs impacted SHD.Methods: All clinically NFAs surgically removed between...

Secondary hormonal deficiency (SHD) in sellar masses (SM) is thought to be partly due to compression of the portal vessels by the enlarging tumour restricting the blood supply to the normal pituitary tissue. However, to date no study has looked at the patterns of SHD in various types of SM and assessed if SHD is related solely to the size of SM or is associated with the underlying pathology. We assessed 914 patients with SM enrolled in our comprehensive pituitary registry sinc...

Patients with sellar masses (SM) undergoing transsphenoidal surgery (TSS) have a significant risk of transient or permanent endocrine dysfunction; therefore, in-hospital endocrinology consultation (IHEC) is recommended for these patients. However, routine assessment of all TSS patients by a specialized team is not feasible outside select centers. We developed an IHEC guide for TSS patients in December 2015 to identify those patients who would require perioperative IHEC. We con...

Introduction: Pituitary apoplexy is a rare clinical syndrome that often involves headache, visual deficits, and endocrine dysfunction resulting from infarction or hemorrhage of a pituitary tumor. Due in part to the rare nature of this condition, there are few large studies on pituitary apoplexy described in the literature. Here, we present a large single center retrospective cohort study of patients with pituitary apoplexy managed surgically or conservatively.<p class="abs...

Introduction: While there is a significant risk of recurrence in nonfunctioning pituitary adenoma (NFPA) after surgery, it is challenging to predict which NFPAs will recur based solely on routine histopathology. To better understand markers of recurrence, we assessed the established tumor markers linked to aggressive tumor behavior including X-linked IAP (XIAP), the most potent inhibitor of the apoptosis protein family, vascular epithelial growth factor (VEGF) which facilitate...

Secondary hormonal deficiency (SHD) is common in patients presenting with nonfunctioning pituitary adenomas (NFA). NFA can either stain for various hormones or be non-hormone staining on immunocytochemistry. To date, no study has assessed the association between staining pattern of NFA and pattern of SHD at presentation. The Halifax Neuropituitary Program has been prospectively collecting comprehensive data on all neuropituitary patients in the province of Nova Scotia, Canada ...